Job description
About SpringWorks Therapeutics
SpringWorks is a clinical-stage biopharmaceutical company applying a precision medicine approach to acquiring, developing and commercializing life-changing medicines for patients living with severe rare diseases and cancer. SpringWorks has a differentiated targeted oncology pipeline spanning solid tumors and hematological cancers, including two late-stage clinical trials in rare tumor types as well as several programs addressing highly prevalent, genetically defined cancers. SpringWorks' strategic approach and operational excellence in clinical development have enabled it to rapidly advance its two lead product candidates into late-stage clinical trials while simultaneously entering into multiple shared-value partnerships with innovators in industry and academia to unlock the full potential for its portfolio and create more solutions for patients with cancer.
We give it our all every day because we believe in the power of targeted oncology to help people with cancer. If you recognize yourself in us, then we'd like to meet you. The answers are waiting – and we need your help finding them.
About the Role:
Reporting to the Director, DMPK, the Scientist I will serve as a representative on Oncology drug discovery project teams to deliver data and conclusions regarding NCEs from a DMPK perspective. This role will contribute to building a culture of scientific excellence, rigorous innovation, collaboration, and teamwork. This individual will have prior, hands-on DMPK and LC-MS/MS experience in the pharmaceutical industry and a track record of scientific achievement. This individual may directly or indirectly train or supervise staff and may manage the activities of CRO partners. This individual will have experience in designing, conducting, troubleshooting, and interpreting in vitro and in vivo DMPK assays and studies in the pharmaceutical/biotech industry.
Responsibilities Include:
- Perform, review, and report data from in vitro assays and in vivo studies to support drug discovery teams; assist in the design of and interpretation of results from in vitro/in vivo studies.
- Report on the DMPK profiles of small molecule discovery compounds using data from solubility, metabolism, permeability, transporter interaction, pharmacokinetic, and other assays/studies.
- Will be responsible for LC-MS/MS systems, including sample preparation, analytical method development, routine maintenance, data interpretation, and troubleshooting.
- Identify new scientific assays and scientific technologies to enhance productivity and efficiency within the DMPK group.
- Collaborate with project teams in identifying research approaches, hypotheses to be tested, and program milestones to produce candidate drugs with desired properties.
- Contribute key findings for presentations to internal/external stakeholders at scientific meetings and conferences.
- Manage DMPK data in a discovery chemistry database system.
- Prepare and present key findings to internal team.
- Manage outsourced studies.
- Model SpringWorks Values and exemplify scientific excellence.
- Perform other duties and responsibilities as assigned.
About You: Required Education, Skills, and Experience
- Ph.D. degree in a biology-, chemistry-, or pharmaceutical-related field and 2+ years' experience, Hands-on DMPK and LC-MS/MS experience in biotech/pharma; ideally, in a drug discovery/development setting or Master's degree in in a biology-, chemistry-, or pharmaceutical-related field 5+ years' experience Hands-on DMPK and LC-MS/MS experience in biotech/pharma; ideally, in a drug discovery/development setting.
- Hands-on experience performing a selection of in vitro DMPK assays, some examples of which are: solubility (kinetic and thermodynamic), permeability (PAMPA, Caco-2, MDCK), metabolic stability (liver microsomes, hepatocytes), other CYP-related assays (inhibition, induction, reaction phenotyping), protein binding, and blood-to-plasma partitioning.
- Awareness of principles, theories, and practices covering in vitro models (above), in vivo pharmacokinetic studies, and how in vitro and in vivo models relate.
- Awareness of principles of liquid chromatography coupled to mass spectrometers with atmospheric pressure ionization sources.
- Experienced in the use, routine maintenance, and troubleshooting of LC-MS/MS instrumentation.
- Experienced in the interpretation, analysis, documentation of key findings.
- Takes accountability for own professional development.
- Ability to collaborate with other scientists.
- Effective organizational, interpersonal and communication skills.
- Excellent written and oral communication skills.
- Ability to communicate technical data to cross-functional team members and program leaders.
- This position is lab-based and will be required to be on-site 5 days a week.
The expected salary range for this position is $103,927.00 - $136,500.00. Actual pay will be determined based on experience, qualifications, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
We also offer a comprehensive benefits package for our team of SpringWorkers and their families, including competitive compensation, annual cash bonuses and equity grants, 401K matching, fully covered medical, dental, and vision plans, and a full week of holiday break at year end. It's the right thing to do – and helps us be healthy, happy, and at our best for the people who need us.
At SpringWorks, we believe in fostering a culture of belonging. Our Employee Resource Group's (ERG) mission is to boldly live the SpringWorks values, provide resources, and deeply engage SpringWorkers and the communities we serve to foster a culture of belonging. Ensuring diversity, equity, and inclusion are integral to our organization's DNA.
SpringWorks is an equal employment opportunity employer that is strongly committed to equal employment opportunities for all individuals. The Company does not discriminate in employment opportunities or practices on the basis of actual or perceived sex (including pregnancy, childbirth, breast feeding or related medical conditions), gender, gender identity or gender expression, sexual orientation, partnership status, marital status, familial status, pregnancy status, race, color, national origin, ancestry, religion, religious creed, age, alienage or citizenship status, veteran status, military status, physical or mental disability, past or present history of mental disorder, medical condition, AIDS/HIV status, sickle cell or hemoglobin C trait, genetic predisposition, genetic information, protected medical leaves, domestic violence victim status, sex offense or stalking victim status, political affiliation and any and all other characteristics or categories protected by applicable federal, state or local laws.
This Equal Employment Opportunity Policy applies to all aspects of employment, including, without limitation, recruitment, hiring, placement, job assignment, promotion, termination, transfer, leaves of absence, compensation, discipline, and access to benefits and training. Any violation of this Policy will result in disciplinary action up to and including termination of employment.
GDPR Statement: When you apply to a job on this site, the personal data contained in your application will be collected by SpringWorks Therapeutics ("Controller"), which is located at 100 Washington Blvd, Stamford CT 6902 and can be contacted by emailing hr@springworkstx.com . Your personal data will be processed for the purposes of managing Controller's recruitment related activities, which include setting up and conducting interviews and tests for applicants, evaluating and assessing the results thereto, and as is otherwise needed in the recruitment and hiring processes. Such processing is legally permissible under Art. 6(1)(f) of Regulation (EU) 2016/679 (General Data Protection Regulation) as necessary for the purposes of the legitimate interests pursued by the Controller, which are the solicitation, evaluation, and selection of applicants for employment.
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Your personal data will be retained by Controller for as long as Controller determines it is necessary to evaluate your application for employment. Under the GDPR, you have the right to request access to your personal data, to request that your personal data be rectified or erased, and to request that processing of your personal data be restricted. You also have to right to data portability. In addition, you may lodge a complaint with an EU supervisory authority.
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