Sr. Scientist, RNA Engineering

Full Time
Cambridge, MA 02139
Posted
Job description
The Role:
Moderna is working to deliver on the promise of mRNA science to create a new generation of transformative medicines for patients. In our goal to invent best-in-class mRNA medicines, Moderna’s RNA Science team is seeking an experienced, creative scientist with a passion for mRNA therapeutics. In this role, you will have the opportunity to create and test novel RNA design solutions that lead to fit for purpose RNA medicines.

We are looking for a senior scientist with deep expertise in metabolism of mRNA, non-coding RNAs, or both. Hands-on experience in evaluating biological and therapeutic impact of modified nucleotides in RNAs is desirable. Knowledge of the biochemistry of RNA binding proteins and cellular RNA decay pathways, and familiarity with the cellular immune response to foreign nucleic acid delivery is beneficial.

The scientist will collaborate with a multidisciplinary team to discover innovative solutions to drive the next generation of RNA therapeutics. The candidate will be responsible for identifying and evaluating chemical or sequence solutions to engineering RNAs with desirable properties. The scientist will also be responsible for assay development to establish function of designed RNAs in cells. The individual is expected to keep up with new developments in the field of RNA therapeutics and drive actionable information from publications and databases.

Excellent project management, organization and record keeping are a must. Ability to handle multiple projects with aggressive timelines, scientific rigor, innovative thinking, and effective communication skills are essential to success at Moderna.

Here’s What You’ll Do:
Identify novel chemical and sequence modifications to confer desired properties to RNA

Design experiments to evaluate RNA fate in cells using cellular and molecular biology techniques in a variety of cell types

Develop assays to establish mechanistic understanding of unmodified/ modified nucleic acids’ metabolism in cells

Mentor and manage junior colleagues

Work closely with cross-functional teams

Maintain clear scientific records and communicate actionable information routinely

Communicate scientific findings to colleagues and collaborators in formal and informal settings

Collaborate with colleagues in RNA Science, Chemical Biology and Technical Development Teams

Follow Moderna's policies to ensure best practices (e.g., laboratory safety, electronic lab notebook, etc.)

Here’s What You’ll Bring to the Table:
PhD in Molecular Biology, RNA Biology, Biochemistry, Chemical Biology or closely related field with 3-6 years of relevant experience. 2+ years of industry experience is preferred.

Deep understanding of nucleic acid biochemistry and RNA biology

Extensive experience with Biochemistry, Cell Biology and Molecular Biology techniques to enable quantitative studies of RNA metabolism

Excellent interpersonal, organizational, and collaborative skills, attention to detail, and the ability to work independently and effectively in a highly dynamic environment

Ability to quickly master new scientific techniques and concepts

Ability to multi-task to meet timelines and goals

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
Highly competitive and inclusive medical, dental and vision coverage options
Flexible Spending Accounts for medical expenses and dependent care expenses
Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
Family care benefits, including subsidized back-up care options and on-demand tutoring
Free premium access to fitness, nutrition, and mindfulness classes
Exclusive preferred pricing on Peloton fitness equipment
Adoption and family-planning benefits
Dedicated care coordination support for our LGBTQ+ community

Generous paid time off, including:
  • Vacation, sick time and holidays
  • Volunteer time to participate within your community
  • D iscretionary year-end shutdown
  • Paid sabbatical after 5 years; every 3 years thereafter
Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
401k match and Financial Planning tools
Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Complimentary concierge service including home services research, travel booking, and entertainment requests
Free parking or subsidized commuter passes
Location-specific perks and extras!

About Moderna
In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at leavesandaccommodations@modernatx.com. (EEO/AAP Employer) #LI-SP1
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