Job description
Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
Role Summary
The Upstream Development Group within Early Bioprocess Development at VRD in Pearl River, NY, is seeking an experienced Senior Scientist whose work will focus on RNA biochemistry and structure. The successful applicant will play a fundamental role in supporting the upstream mRNA drug substance team in various molecular biology and RNA biochemistry efforts. A comprehensive, hands-on background in all aspects of molecular biology is required, including in vitro transcription, RNA biochemical and structural analysis, molecular cloning, and plasmid construction. There would be particular interest in candidates with a background in NGS-based and Nanopore-based RNA analyses. The incumbent would join a team of scientists well-versed in mRNA production and characterization and would be expected to support and innovate efforts on multiple fronts.
Responsibilities
The primary responsibility would be to lead and innovate efforts in molecular biology and RNA biochemistry/structure work in the group. The incumbent should understand all aspects of molecular biology, including plasmid design, biochemical and structural assays for RNA, and nucleic acid characterization for quality and purity. In addition to the above, the ideal candidate would have hands-on experience performing and analyzing nucleic acid sequencing in the context of RNA structural tools, i.e., SHAPE-MaP, Nanopore, or other affiliated techniques. As well as working with the mRNA team, the incumbent will be working closely with several other teams within and outside of VRD and leading innovation efforts on their own. Data documentation will be performed promptly and compliant, and data presentation will occur within the group, to project teams, and at the departmental level.
Qualifications
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Ph. D with a minimum of 1 year relevant experience. Individuals with an MS/BS that have the expertise appropriate to the specific position
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Supervisory qualification: demonstrated ability in project management, some appreciation or experience in related fields of science.
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Extensive expertise and hands-on experience in molecular biology, RNA biochemistry, cell biology, immunology, or related fields, and a desire to continue working in a laboratory-focused role. Command of analytical techniques such as gel/capillary gel electrophoresis, fragment analyzer, RNA structural analysis, e.g., SHAPE-seq, SHAPE-MaP, DMS-seq, nucleic acid analysis (Sanger, NGS, Nanopore, etc.)
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The candidate should have a desire to build on their knowledge, as well as lead, innovate, recommend, and deploy new strategies, and recommend new technologies.
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Excellent written and oral communication, and highly organized - in terms of goal-setting and achieving for multiple experiments/tasks - are required skills, as well as the ability to give clear, concise direction and provide expectations to direct reports.
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Scientific skills such as developing working hypotheses, developing and validating assays, and data interpretation are required.
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Ability to troubleshoot and perform complex data analysis, the ability to effectively manage, organize, and prioritize multiple projects and meet deadlines
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A team player with strong interpersonal and organizational skills are a must. The candidate should possess a strong work ethic and collaborative spirit.
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Experience managing and/or training junior colleagues
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Experience in leading complex projects or teams
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Act as a technical and scientific resource within own project team/discipline
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Ability to integrate intellectually complex and diverse pieces of information
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Develop the ability to assess technical risk.
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Use own scientific judgment to apply and adapt standard methods and techniques
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Ability to plan experimental workflows for multiple experiments
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Ability to work independently
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Collaborates in a team environment
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Has experience in preparing and making comprehensive presentations
PHYSICAL/MENTAL REQUIREMENTS
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Mental requirements are a detailed understanding of the scientific subject matter, an ability to make scientific judgments and perform complex data analysis.
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Physical requirements include lifting, sitting, standing, walking, and bending; the ability to sit for an extended time at a biosafety cabinet and computer
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Ability to work during off-time when experiments require that. Ability to travel to attend workshops, trainings, and conferences.
Other Job Details:
Eligible for relocation package
Eligible for employee referral bonus
#LI-PFE
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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