Scientist 3 Translational Imaging

Full Time
San Francisco, CA
Posted
Job description

The Position

Genentech's Research and Early Development organization (gRED) is seeking a motivated Molecular Imaging scientist to join the Department of Translational Imaging, a highly collaborative group devising and developing imaging biomarkers to support our pipeline of novel therapeutics, including cell-based therapies. The work is a collaboration of imaging experts with many other scientists and clinicians in areas including neuroscience, immunology, and cancer. This individual contributor role, at the Scientist 3 level, is based on campus in our state-of-the-art imaging facility. You would be hands-on acquiring and analyzing PET/CT data from varied in vivo models, then discussing results with colleagues expert in radiochemistry and tracer development, peptide and protein engineering, pharmacokinetic modeling, and AI-enabled image processing, as well as biologists expert in the therapeutics we are supporting.

Responsibilities

According to Department needs at the time and considering your interests and skills. Training will be given where necessary but responsibilities will include some or all of the following:

  • Devise experimental protocols in accordance with scientific, logisitic, welfare, and ethical considerations

  • Prepare subjects for imaging including IV catheter placement and timed radiotracer administration

  • PET/CT data acquisition, supervision of semi-automated image reconstruction and analysis workflows

  • Sample collection to enable tracer stability and metabolite formation assays

  • Work safely and considerately in the laboratory in compliance with training and best practices

  • Review, QC, and annotation of the images, generation of statistics and plots from regions of interest

  • Curate image and study metadata; data wrangling for computational pipelines (modeling, dosimetry, AI/ML etc)

  • Iterate with colleagues and IT partners in image analytics to improve and automate our analysis tools

  • Perform periodic instrument calibrations, lab safety surveys; facilitate service visits and software updates

  • Undertake validation experiments ex vivo, e.g. autoradiography, gamma counting, FACS.

  • Present and discuss results at internal meetings and external conferences when appropriate

  • Work to team timelines and regularly update colleagues and project managers on progress and difficulties

  • Co-author publications and potentially patents describing impactful and novel work

Qualifications

  • Postgraduate degree with 2 or more years directly relevant experience, OR

  • Bachelor’s degree with several years of directly relevant experience in industry.

  • Demonstrated ability to independently perform and analyze preclincal PET experiments with living subjects.

  • Working knowledge of one or more languages for data wrangling and analysis (Python, R, Matlab, JavaScript)

Beneficial experience

  • Fluency with some radiologic image analysis toolset, ideally Invicro’s VivoQuant and iPACS

  • Experience with maintaining and operating preclinical imaging equipment, ideally PET/CT

  • Experience of fetching images from a database and routing to analysis pipelines in Linux HPC environment

  • Experience with wet lab techniques e.g. cell culture, inoculation, necropsy, FACS, etc.

  • Experience with using dynamic PET data for PK modeling, radiation dosimetry, etc

Relocation benefits are available for this position

The expected salary range for this position based on the primary location of South San Francisco, California is $98,200 to $182,400.00 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

#researcherjob

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

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