Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future – here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

We are now recruiting an experienced Scientist with knowledge, animal research experience and in vivo technical skills in cardiovascular disease, especially in the disease areas of heart failure, cardiomyopathies, pulmonary hypertension, and/or cardiac regeneration to join Bioscience Cardiovascular department within the Early Cardiovascular, Renal and Metabolism (eCVRM) therapeutic area at AstraZeneca in Gaithersburg, Maryland. It is a unique opportunity for a scientist who want to explore the career in early drug discovery in pharmaceutical industry.

The successful candidate should have hands-on in vivo pharmacology experience, particularly in rodent models of cardiovascular diseases, heart failure and cardiomyopathies. Expertise in working with rodent ex vivo lab techniques including blood cells panel, biomarker, tissue gene expression, ELISAs, western blot analysis etc. is required. The successful candidate will be greatly involved with experimental work, including the design, execution and interpretation of preclinical experimental data. Additionally, the candidate will present results to CVRM group and project team meetings. The ability to work well in a team environment, and to interact with departments outside of CVRM is essential for this position.

ABOUT ASTRAZENECA

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

In the Bioscience Cardiovascular department within Early CVRM, we focus on identifying and validating new drug targets for patients with cardiovascular disease and heart failure as well as evaluating pharmacological aspects, e.g. efficacy, target related pharmacology and mechanism of action, of new compounds crafted to hit these targets. The team delivers key data to projects across all phases of the drug discovery and development, and we work with different modalities such as stem cells, AAV, antibodies, small molecules, modified mRNA, antisense oligonucleotides and peptides.

Requirements:

Education and Experience:

Degree in a biological science field PhD and 1+ years relevant experience or MS and 3+ years of relevant experience or BS and 5+ years of relevant experience

Core responsibilities:

• Highly proficient in working with rodent models of cardiovascular diseases, heart failure and cardiomyopathies – hands on expertise in animal handling, dosing (SC, IV, PO and IM), and necropsy tissue collections (essential)

• Support drug discovery studies to deliver novel drugs to treat cardiovascular disease and heart failure. Administration of CVRM therapeutic modalities to CVRM rodent models (essential)

• Independently execute ex vivo analysis of blood/tissue samples including blood cell panel, qPCR gene expression, western blots, and ELISAs (essential)

• Design and conduct in vivo studies to support therapeutic drug development in disease models as well as in pharmacokinetics, pharmacodynamics, and efficacy studies. Take part in all experimental work, including the design, analysis and interpretation of data from these experiments (essential)

• Prepare and present scientific data to CVRM in vivo group meetings (essential) and project team meetings (desirable)

• Work in a cross-functional project team with responsibility of making decisions and recommendations for program in vivo pharmacology plans (essential)

• Develop an understanding of the scientific basis of the CVRM project pipeline, to be able to successfully execute experiments needed to meet the requirements of the projects involved with (essential)

• Develop and validate new in vivo cardiovascular and heart failure disease models with comorbidities as required, and implement novel animal models and technologies in the pipeline studies (essential)

• Experience in surgical procedures desirable

• Experience in pharmaceutical industry desirable

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge science and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next?

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!